Last update
5/15/2025
Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
Supplement Facts
Serving Size:  1/4 Level Teaspoon (1.1 g)
Amount Per Serving
%DV
Vitamin C (Ascorbic Acid)
1.1 g (1,100 mg) 
1222% 

Top Medical Research Studies

7
Vitamin C aids immune function
We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
Read More
7
Vitamin C effects on CFS
We investigated the potential benefits of vitamin C infusions in treating Chronic Fatigue Syndrome (CFS) through a clinical study. This study looked at patients diagnosed with chronic pneumonia and CFS, focusing on how these patients responded to different vitamin C infusion treatments—both those without the addition of dehydroepiandrosterone (DHEA) and those that included it.

Our analysis revealed that a significant portion of patients experienced symptoms aligning with CFS, characterized by a prolonged illness that required extensive medical care. Patients tended to respond better to a combination of both the old and new vitamin C infusions rather than relying solely on the traditional treatment.

Notably, the combined treatment was more effective, suggesting that there may be underlying issues related to hormone levels in CFS patients that are influenced by vitamin C therapy. However, we also noted potential side effects with the sole use of the new vitamin C infusion. A careful balance between the different infusion approaches is crucial for achieving the best outcomes in CFS management.

Overall, while we observed some promising responses to vitamin C treatments, more research is necessary to fully understand its effectiveness and to optimize treatment strategies for those suffering from chronic fatigue syndrome.
Read More
9
Vitamin C therapy shows potential
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.

What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.

Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
Read More

Most Useful Reviews

9
Reduced fatigue
9 people found this helpful
It should be in every home. A lack of Vitamin C leads to issues like bleeding gums, tooth loss, frequent colds, and chronic fatigue syndrome. The daily dose of Vitamin C is 100 mg, which is safe even in larger amounts. The powder has a tart taste, but I've grown to like it. For a toned appearance, I recommend taking Vitamin C along with collagen regularly. This helps in reducing the frequency of illnesses in winter. Make sure to choose quality products without unnecessary additives.
Read More
8.5
Boosted spirits
4 people found this helpful
These vitamins are quite powerful. While they require a significant intake, they keep my spirit bright and help with my chronic fatigue syndrome. I purchased a large container and have been using it for about a year now.
Read More
9
Brighter skin tone
2 people found this helpful
I highly recommend this. My chronic fatigue syndrome has visibly decreased, and my skin tone appears brighter. If you’re sceptical about Vitamin C, I suggest trying a small dose first.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
  • All Researches
9
Vitamin C therapy shows potential
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.

What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.

Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
Read More
8
Vitamin C may aid CFS management
We aimed to understand whether vitamin C infusion treatments could benefit those suffering from chronic fatigue syndrome (CFS). Specifically, we looked at two types of vitamin C infusion sets: one that included dehydroepiandrosterone (the new set) and one without it (the old set). Our investigation involved a male patient diagnosed with CFS, monitoring his health from August 1995 to May 1996.

Initially, the old infusion method, alongside some antibiotics, showed effectiveness in managing the patient’s pneumonia, which was a part of the CFS symptoms. However, over time, pneumonia symptoms returned, prompting us to alternate between the old and new vitamin C treatments along with longer antibiotic use. Remarkably, this switch led to a notable reduction in pneumonia signs.

We found that the new vitamin C infusion treatment dramatically increased urine excretion of certain hormones, suggesting an enhancement of the body’s steroid activities. Notably, some evidence indicated that the dehydroepiandrosterone was converted into testosterone, which could positively influence the CFS control. However, our searches for changes in immune response didn’t yield significant results.

Ultimately, our observations suggest that the new vitamin C treatment could help manage CFS by boosting cortisol and testosterone levels, but additional studies would be necessary to fully understand its effectiveness in isolation.
Read More
7
Vitamin C aids immune function
We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.
Read More
7
Vitamin C effects on CFS
We investigated the potential benefits of vitamin C infusions in treating Chronic Fatigue Syndrome (CFS) through a clinical study. This study looked at patients diagnosed with chronic pneumonia and CFS, focusing on how these patients responded to different vitamin C infusion treatments—both those without the addition of dehydroepiandrosterone (DHEA) and those that included it.

Our analysis revealed that a significant portion of patients experienced symptoms aligning with CFS, characterized by a prolonged illness that required extensive medical care. Patients tended to respond better to a combination of both the old and new vitamin C infusions rather than relying solely on the traditional treatment.

Notably, the combined treatment was more effective, suggesting that there may be underlying issues related to hormone levels in CFS patients that are influenced by vitamin C therapy. However, we also noted potential side effects with the sole use of the new vitamin C infusion. A careful balance between the different infusion approaches is crucial for achieving the best outcomes in CFS management.

Overall, while we observed some promising responses to vitamin C treatments, more research is necessary to fully understand its effectiveness and to optimize treatment strategies for those suffering from chronic fatigue syndrome.
Read More
4
Vitamin C in complex disease management
We explored the role of high-dose vitamin C infusions combined with dehydroepiandrosterone-cortisol in treating interstitial pneumonia, often linked with chronic fatigue syndrome. In a clinical setting since 1996, we've seen these treatments used for controlling symptoms and potentially improving outcomes in autoimmune disease management.

However, our findings highlight four key issues. First, it is still debated whether these treatments should continue on a maintenance basis when no acute symptoms are present. Some evidence suggests their ongoing use is crucial for halting an evolving bacterial colony in patients with immune deficiencies.

Second, we noted an emerging problem with drug-resistant bacteria, which posed challenges in treatment effectiveness. New antibiotics, like kanamycin, showed promise in addressing this resistance and improving pneumonia symptoms.

Third, we observed a decline in bone marrow function in one patient over a nine-year observation period, indicating potential fibrosis similar to that seen in lung tissue.

Lastly, we encountered a case where a female patient developed breast cancer during treatment, raising concerns about the risks of prolonged autoimmune conditions in older adults. Interestingly, dehydroepiandrosterone appeared to support hepatic recovery during cancer chemotherapy, suggesting complex interactions between treatments and patient responses.

Overall, while vitamin C plays a role in the treatment approach, the complexities of chronic fatigue syndrome and interstitial pneumonia present challenges that require further investigation.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced fatigue
9 people found this helpful
It should be in every home. A lack of Vitamin C leads to issues like bleeding gums, tooth loss, frequent colds, and chronic fatigue syndrome. The daily dose of Vitamin C is 100 mg, which is safe even in larger amounts. The powder has a tart taste, but I've grown to like it. For a toned appearance, I recommend taking Vitamin C along with collagen regularly. This helps in reducing the frequency of illnesses in winter. Make sure to choose quality products without unnecessary additives.
Read More
8.5
Boosted spirits
4 people found this helpful
These vitamins are quite powerful. While they require a significant intake, they keep my spirit bright and help with my chronic fatigue syndrome. I purchased a large container and have been using it for about a year now.
Read More
9
Brighter skin tone
2 people found this helpful
I highly recommend this. My chronic fatigue syndrome has visibly decreased, and my skin tone appears brighter. If you’re sceptical about Vitamin C, I suggest trying a small dose first.
Read More
9
Fatigue improvement
1 people found this helpful
Vitamin seeds are essential for life. I have been using Megados for five years now, and it provides me with daily pleasure and helps improve my chronic fatigue syndrome.
Read More
7.5
Less fatigue
1 people found this helpful
This product has been good for my chronic fatigue syndrome. Although I had to reduce the dose a little after four days, I experienced less fatigue and issues related to digestion. I recommend it.
Read More

Frequently Asked Questions

7.5
Less fatigue
1 people found this helpful
This product has been good for my chronic fatigue syndrome. Although I had to reduce the dose a little after four days, I experienced less fatigue and issues related to digestion. I recommend it.
7.5
Smooth skin
5 people found this helpful
The megadose of Vitamin C is effective. I take 10g daily, and after about ten days, I've noticed my skin is much smoother, and I feel less chronic fatigue syndrome, especially in the mornings. It has really made a difference in how I feel.
6
Heartburn issues
2 people found this helpful
Megados has been effective for treating my chronic fatigue syndrome. While it helps with fatigue recovery, I’ve experienced gas, heartburn, and nausea. I even purchased liposomal vitamins due to the heartburn issue.
9
Brighter skin tone
2 people found this helpful
I highly recommend this. My chronic fatigue syndrome has visibly decreased, and my skin tone appears brighter. If you’re sceptical about Vitamin C, I suggest trying a small dose first.
8.5
Boosted spirits
4 people found this helpful
These vitamins are quite powerful. While they require a significant intake, they keep my spirit bright and help with my chronic fatigue syndrome. I purchased a large container and have been using it for about a year now.
7.5
Reflects improvement
This product has had fantastic effects on my chronic fatigue syndrome. I’ve experienced reduced fatigue and improved skin quality after consistent use. I recommend taking it with a straw to protect my teeth.
9
Reduced fatigue
9 people found this helpful
It should be in every home. A lack of Vitamin C leads to issues like bleeding gums, tooth loss, frequent colds, and chronic fatigue syndrome. The daily dose of Vitamin C is 100 mg, which is safe even in larger amounts. The powder has a tart taste, but I've grown to like it. For a toned appearance, I recommend taking Vitamin C along with collagen regularly. This helps in reducing the frequency of illnesses in winter. Make sure to choose quality products without unnecessary additives.
8
Immunity boost
1 people found this helpful
This odourless crystalline powder has helped strengthen my immune system. For chronic fatigue syndrome, I find taking 500-1000 mg after meals effective. I've paired it with collagen in the mornings and am pleased with the quality and results.
9
Less fatigue
I started taking powdered vitamin C after noticing that pills were ineffective for my chronic fatigue syndrome. The powder works better for absorption, significantly reducing my fatigue.
7.5
Health improvement
1 people found this helpful
I chose the powder form for its absorption rate, which has turned out well. It's easier to consume than anticipated. My chronic fatigue syndrome has improved, and I feel healthier overall. I intend to recommend it to my friends.
6
Less fatigue
2 people found this helpful
I bought this for its mega-doses of Vitamin C. Since I started taking 10g daily, my chronic fatigue syndrome has noticeably decreased. I'm keen to continue with this regimen.
9
Vitamin C therapy shows potential
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.

What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.

Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
7
Vitamin C effects on CFS
We investigated the potential benefits of vitamin C infusions in treating Chronic Fatigue Syndrome (CFS) through a clinical study. This study looked at patients diagnosed with chronic pneumonia and CFS, focusing on how these patients responded to different vitamin C infusion treatments—both those without the addition of dehydroepiandrosterone (DHEA) and those that included it.

Our analysis revealed that a significant portion of patients experienced symptoms aligning with CFS, characterized by a prolonged illness that required extensive medical care. Patients tended to respond better to a combination of both the old and new vitamin C infusions rather than relying solely on the traditional treatment.

Notably, the combined treatment was more effective, suggesting that there may be underlying issues related to hormone levels in CFS patients that are influenced by vitamin C therapy. However, we also noted potential side effects with the sole use of the new vitamin C infusion. A careful balance between the different infusion approaches is crucial for achieving the best outcomes in CFS management.

Overall, while we observed some promising responses to vitamin C treatments, more research is necessary to fully understand its effectiveness and to optimize treatment strategies for those suffering from chronic fatigue syndrome.
4
Vitamin C in complex disease management
We explored the role of high-dose vitamin C infusions combined with dehydroepiandrosterone-cortisol in treating interstitial pneumonia, often linked with chronic fatigue syndrome. In a clinical setting since 1996, we've seen these treatments used for controlling symptoms and potentially improving outcomes in autoimmune disease management.

However, our findings highlight four key issues. First, it is still debated whether these treatments should continue on a maintenance basis when no acute symptoms are present. Some evidence suggests their ongoing use is crucial for halting an evolving bacterial colony in patients with immune deficiencies.

Second, we noted an emerging problem with drug-resistant bacteria, which posed challenges in treatment effectiveness. New antibiotics, like kanamycin, showed promise in addressing this resistance and improving pneumonia symptoms.

Third, we observed a decline in bone marrow function in one patient over a nine-year observation period, indicating potential fibrosis similar to that seen in lung tissue.

Lastly, we encountered a case where a female patient developed breast cancer during treatment, raising concerns about the risks of prolonged autoimmune conditions in older adults. Interestingly, dehydroepiandrosterone appeared to support hepatic recovery during cancer chemotherapy, suggesting complex interactions between treatments and patient responses.

Overall, while vitamin C plays a role in the treatment approach, the complexities of chronic fatigue syndrome and interstitial pneumonia present challenges that require further investigation.

References

  1. Mikirova N, Hunninghake R. Effect of high dose vitamin C on Epstein-Barr viral infection. Med Sci Monit. 2014;20:725. 10.12659/MSM.890423
  2. Kodama M, Kodama T. Four problems with the clinical control of interstitial pneumonia, or chronic fatigue syndrome, using the megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex. In Vivo. 2006;20:285.
  3. Kodama M, Kodama T. The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex. Int J Mol Med. 2005;15:109.
  4. Kodama M, Kodama T, Murakami M. The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). II. Characterization of CFS patients with special reference to their response to a new vitamin C infusion treatment. In Vivo. 1996;10:585.
  5. Kodama M, Kodama T, Murakami M. The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient. In Vivo. 1996;10:575.
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